What medications increase risk of osteoporosis?
The medications most commonly associated with osteoporosis include phenytoin, phenobarbital, carbamazepine, and primidone. These antiepileptic drugs (AEDs) are all potent inducers of CYP-450 isoenzymes.
Does carbamazepine increase risk of osteoporosis?
Data suggests that long-term use of carbamazepine, phenytoin, primidone, and sodium valproate is associated with decreased bone mineral density that may lead to osteopenia, osteoporosis, and increased fractures.
Are athletes more prone to osteoporosis?
Low bone mass poses a particular challenge for athletes because it predisposes to stress-related bone injuries and increases the risk of osteoporosis and insufficiency fractures with aging.
Can osteosarcoma cause osteoporosis?
Though survival rates of children with osteosarcoma have improved in recent years, many of these children go on to develop osteoporosis as they age, according to a team of researchers in Korea.
What drugs affect bone density?
Many drugs can affect bone metabolism. As an example, heparin, warfarin, cyclosporine, glucocorticoids, medroxyprogesterone acetate, cancer drugs, and thyroid hormone can cause bone loss, while thiazide diuretics can minimize bone loss [1,2]. This topic will review the skeletal effects of some of these drugs.
What increases your risk of osteoporosis?
The risk of getting osteoporosis increases with age as bones naturally become thinner….Lifestyle factors.
- Smoking.
- Alcohol use.
- Getting little or no exercise.
- Being small-framed or thin.
- A diet low in foods containing calcium and vitamin D.
Do antiepileptics cause osteoporosis?
Taking enzyme-inducing AEDs Taking high doses of several different AEDs for many years may contribute to the risk of developing osteoporosis. Studies have shown that some enzyme-inducing AEDs may increase the levels of chemicals in the liver that destroy vitamin D, reducing the amount of vitamin D in the body.
Does valproic acid cause osteoporosis?
Although valproic acid is considered to be a generally well–tolerated drug, numerous studies have shown an increased bone loss and fracture risk in patients treated with VPA.
Which athletes are at greatest risk of osteoporosis?
Osteoporosis in athletes is sports specific; there is a much greater incidence in appearance sports, such as diving, figure skating, gymnastics, synchronised swimming, and ballet. Endurance sports, which involve distance running, particularly in marathon runners.
Are runners at risk of osteoporosis?
Recent studies show that women who run long distances have lower bone density than women who just sit around. That’s not good. Low bone density is a sign of osteoporosis and high risk of bone fracture.
How does osteosarcoma affect the bones?
Osteosarcoma begins when a healthy bone cell develops changes in its DNA. A cell’s DNA contains the instructions that tell a cell what to do. The changes tell the cell to start making new bone when it isn’t needed. The result is a mass (tumor) of poorly formed bone cells that can invade and destroy healthy body tissue.
Does myeloma cause osteoporosis?
Myeloma cells grow in the bone marrow and cortical bone, causing local bone damage or generalized thinning of the bone, which is called osteoporosis. This makes the bone more likely to break. The back or ribs are the most common sites of bone pain, but any bone can be affected.