What is Iupac name of cisplatin?

Cisplatin, cisplatinum or cis-diamminedichloroplatinum(II) (CDDP) is a platinum-based chemotherapy drug used to treat various types of cancers, including sarcomas, some carcinomas (e.g. small cell lung cancer, and ovarian cancer), lymphomas and germ cell tumors.

How do you synthesize cisplatin?

The synthesis of monofunctional complexes can be accomplished by stirring a mixture of cisplatin and one equiv of the N-heterocycle in water at 50–60 °C for several days. This reaction proceeds by direct substitution of the chloride ligand by the N-heterocycle.

What is cisplatin made from?

Cisplatin is used to treat various types of cancer. It is a chemotherapy drug that contains platinum. It is used to slow or stop cancer cell growth.

What are the uses of cisplatin?

Cisplatin is a chemotherapy drug used to treat testicular, ovarian, bladder, head and neck, lung and cervical cancer. It may also be used to treat other cancers.

How much cisplatin can you have?

A typical dose is 20 mg/m2 or more once every 3 to 4 weeks. For treatment of cervical cancer cisplatin is used in combination with radiotherapy. A typical dose is 40 mg/m2 weekly for 6 weeks.

What is the use of cisplatin?

Cisplatin is a chemotherapy drug used to treat testicular, ovarian, bladder, head and neck, lung and cervical cancer. It may also be used to treat other cancers. It is best to read this information with our general information about chemotherapy and the type of cancer you have.

What is the most common side effect of cisplatin?

The following side effects are common (occurring in greater than 30%) for patients taking Cisplatin: Nausea and vomiting. Nausea may last up to 1 week after therapy. Anti-nausea medication is given before the infusion, and a prescription is also given for use after.

Which is the correct chemical formula for cisplatin?

Formula and structure: The cisplatin chemical formula is [Pt (NH 3) 2 Cl 2] and its molar mass is 300.01 g mol -1. Cisplatin is an coordinated molecule formed by the metal platinum Pt which is coordinated to 2 atoms of chloride (Cl) and 2 ammonia (NH 3). The substituent atoms are – cis because these lie on the same plane in the molecule.

What is the molecular weight of cis platin?

cis-Platin PubChem CID 441203 Molecular Weight 300 g/mol Component Compounds CID 222 (Ammonia) CID 2768 (Dichloroplat Date s Modify 2021-05-01 Create 2004-09-16

How does the platinum complex in cisplatin work?

The way that cisplatin operates is by forming a platinum complex inside of a cell which binds to DNA. When DNA is cross-linked in this manner, the cell undergoes apoptosis, or systemic cell death.

How does cisplatin react with DNA during hydrolysis?

An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle.