How is benzocaine synthesized?

How is benzocaine synthesized?

Local Anesthetics 1). The classic, optimal way of benzocaine synthesis is the reduction of the nitro group of the ethyl ester of 4-nitrobenzoic acid to benzocaine by hydrogen, which generates directly in the reaction medium by the reaction of iron filings with dilute acids [24–26].

How does Le Chatelier’s principle influence the benzocaine synthesis?

Le Chatelier’s Principle can be exploited to push the reaction toward the product side. In this synthesis of benzocaine, by using microwave heating, we will be able to successfully complete the actual reaction of benzocaine in just a couple of minutes.

How do you calculate theoretical yield of benzocaine?

Calculations: Theoretical yield= 0.126g 4-aminobenzoic acid x 165.192g benzocaine / 137.138g 4- aminobenzoic acid =0.152 g benzocaine Percent yield= 0.035 g product / 0.152 g theoretical x 100 = 23% Recorded melting point range: 92 to 94 °C ℃ Conclusion: The purpose of this experiment was to synthesize benzene in order …

How do you purify benzocaine?

Purifying the Benzocaine. a) Add a few mL of hot ethanol and heat the mixture on the steam bath until all the oil dissolves. b) Add water (drop wise!) to the alcohol solution until cloudiness just appears and then add a few drops of ethanol. Cool the mixture, with occasional VIGOROUS swirling, in an ice bath.

Where is benzocaine metabolized?

Benzocaine is metabolized into at least three compounds by acetylation and hydrolysis. Benzocaine and its acetylated metabolite are rapidly eliminated across the gills while the more polar de-ethylated and de-ethylated-acetylated metabolites are excreted at slower rates primarily in the urine.

What is meant by Le Chatelier’s principle?

: a statement in physics and chemistry: if the equilibrium of a system is disturbed by a change in one or more of the determining factors (as temperature, pressure, or concentration) the system tends to adjust itself to a new equilibrium by counteracting as far as possible the effect of the change.

What is the molecular weight of benzocaine?

165.19 g/mol
Benzocaine/Molar mass

Is benzocaine acidic or basic?

Benzocaine is a benzoate ester having 4-aminobenzoic acid as the acid component and ethanol as the alcohol component.

What can benzocaine be used for?

It works by blocking nerve signals in your body. Benzocaine topical is used to reduce pain or discomfort caused by minor skin irritations, sore throat, sunburn, vaginal or rectal irritation, ingrown toenails, hemorrhoids, and many other sources of minor pain on a surface of the body.

What is the gas that is evolved during the neutralization?

So, we can say that sodium bicarbonate is a weak base. reacts with acetic acid, a neutralization reaction takes place and an aqueous salt of sodium acetate is formed along with the evolution of carbon dioxide gas. The gas evolved in the reaction is carbon dioxide, which is a colourless and odourless gas.

Where is benzocaine from?

Benzocaine is a chemical compound derived from para-aminobenzoic acid and ethanol. It is a white, odorless, crystalline powder. It acts on neuronal membranes and blocks nerve signals in the body. Its numbing effects are temporary.

How is benzocaine synthesis used in organic chemistry?

Benzocaine Synthesis I. Introduction Esters are important compounds in organic chemistry. They are used in numerous types ofsynthetic reactions, to create different products for a vast array of purposes, including medicinaland cosmetic. To produce an ester, one can utilize an esterification reaction.

How to make benzocaine from para-aminobenzoic acid?

In step 1 common reduction of aromatic para-nitrobenzoic acid by tin and hydrochloric acid to para-aminobenzoic acid and in step 2 esterification of para-aminobenzoic acid by sulphuric acid and ethanol to benzocaine occurring called Fischer esterification.1 Aim: To prepare Benzocaine from p- nitrobenzoic acid.

Can a benzocaine be extracted from sodium bisulfate?

Under these conditions, much of the nonionic benzocaine formed in the experiment should remain dis- solved, and some ionic sodium bisulfate and unreacted sodium p–aminobenzoate may precipitate. Extraction of ths mixture with ether permits the separation of the benzocaine from the ionic compounds.

What is the melting point of benzocaine in the lab?

The actual yield was124.0mg, giving a percent yield of 85.8%. This is a high percent yield, indicating a successfulsynthesis. The melting point recorded in lab was 88-89⁰C; this is very close to the literaturevalue of 88-90⁰C. This accuracy in melting point indicates a pure product. Impurities in the 4