Why is atovaquone used with proguanil?

Why is atovaquone used with proguanil?

Atovaquone/proguanil is a fixed-dose combination tablet of two antimalarial agents and is highly effective for the prevention of Plasmodium falciparum malaria. In combination with proguanil, the ability of atovaquone to inhibit parasitic mitochondrial electron transport is markedly enhanced.

What is the use of proguanil hydrochloride?

Proguanil is a medication indicated for prophylaxis and treatment of Plasmodium falciparum malaria. Proguanil is a prophylactic antimalarial drug, which works by stopping the malaria parasite, Plasmodium falciparum and Plasmodium vivax, from reproducing once it is in the red blood cells.

What is the brand name of atovaquone proguanil?

Malarone is a combination of two drugs, atovaquone plus proguanil, in one tablet. It is available in the United States as the brand name, Malarone.

Is Malarone and chloroquine the same?

Malarone (Atovaquone / Proguanil) Effectively prevents and treats malaria, and treats a certain type of intestinal infection but can cause serious side effects in certain people. chloroquine is generally safe to use during pregnancy and for children. You can take chloroquine with or without food.

What are the side effects of atovaquone?

Atovaquone may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • nausea.
  • vomiting.
  • diarrhea.
  • headache.
  • dizziness.
  • anxiety.
  • difficulty falling asleep or staying asleep.

Is atovaquone proguanil harmful to humans?

Atovaquone-proguanil is well tolerated, and side effects are rare. The most common adverse reactions reported are stomach pain, nausea, vomiting, and headache.

How long should you use proguanil?

Proguanil should be taken for a week before entering an area where malaria occurs. This is to ensure there is sufficient medicine in your bloodstream to give you the required protection. You should continue to take proguanil throughout your stay and for a further four weeks after you have left the area.

Which antimalarial drug is best?

When several different drugs are recommended for an area, the following table might help in the decision process.

  • Atovaquone/Proguanil (Malarone)
  • Chloroquine.
  • Doxycycline.
  • Mefloquine.
  • Primaquine.
  • Tafenoquine (ArakodaTM)

What is the most effective malaria drug?

Intravenous quinine, usually formulated as a dihydrochloride salt, is currently the most widely used agent in the treatment of severe falciparum malaria.

What is the best anti malaria drug?

ACT is a combination of two or more drugs that work against the malaria parasite in different ways. This is usually the preferred treatment for chloroquine-resistant malaria….Medications

  • Atovaquone-proguanil (Malarone)
  • Quinine sulfate (Qualaquin) with doxycycline (Oracea, Vibramycin, others)
  • Primaquine phosphate.

What are the side effects to hydroxychloroquine?

Hydroxychloroquine may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • headache.
  • dizziness.
  • loss of appetite.
  • nausea.
  • diarrhea.
  • stomach pain.
  • vomiting.
  • rash.

How long does atovaquone stay in your system?

Elimination: The elimination half-life of atovaquone is about 2 to 3 days in adult patients. The elimination half-life of proguanil is 12 to 21 hours in both adult patients and pediatric patients, but may be longer in individuals who are slow metabolizers.