What is MODY2?

What is MODY2?

MODY 2 is a form of maturity onset diabetes of the young. MODY 2 is due to any of several mutations in the GCK gene on chromosome 7 for glucokinase. Glucokinase serves as the glucose sensor for the pancreatic beta cell. Normal glucokinase triggers insulin secretion as the glucose exceeds about 90 mg/dl (5 mM).

What causes MODY2?

Maturity-onset diabetes of the young type 2 (MODY2) is an autosomal dominant inherited disease caused by heterozygous inactivating mutations in the glucokinase (GCK) gene and is characterized by mild noninsulin-dependent fasting hyperglycemia. It is treated with diet only, and complications are extremely rare.

Is MODY diabetes bad?

Like other types of diabetes, MODY causes high blood sugar levels. If you don’t get treatment, over time it can lead to complications like: Nerve damage. Heart disease.

Is MODY a form of type 2 diabetes?

MODY is a rare form of diabetes which is different from both type 1 and type 2 diabetes, and runs strongly in families. MODY is caused by a mutation (or change) in a single gene. If a parent has this gene mutation, any child they have, has a 50% chance of inheriting it from them.

What are the symptoms of MODY?

HNF1A-MODY and HNF4A-MODY have similar signs and symptoms that develop slowly over time. Early signs and symptoms in these types are caused by high blood sugar and may include frequent urination (polyuria), excessive thirst (polydipsia), fatigue, blurred vision, weight loss, and recurrent skin infections.

When should you suspect monogenic diabetes?

Doctors consider factors that may suggest monogenic diabetes: Being diagnosed in the first six months of life. Having other conditions caused by a specific gene mutation, such as cysts in the kidneys. Not being obese, or having diabetic family members who are normal weight.

Which MODY is most common?

The different types of MODY are distinguished by their genetic causes. The most common types are HNF1A-MODY (also known as MODY3), accounting for 50 to 70 percent of cases, and GCK-MODY (MODY2), accounting for 30 to 50 percent of cases.

How much does MODY testing cost?

The cost of genetic testing was set at 2,580 USD per individual tested, reflecting the cost of simultaneously sequencing GCK, HNF1A, and HNF4A (Commercial Reference Laboratory pricing).

What does C-peptide tell you?

C-peptide level is based on blood sugar level. C-peptide is a sign that your body is producing insulin. A low level (or no C-peptide) indicates that your pancreas is producing little or no insulin. A low level may be normal if you have not eaten recently. Your blood sugar and insulin levels would naturally be low then.

How do you test for MODY?

How is MODY Diagnosed? A blood sugar test is the first step toward diagnosing MODY. If your results indicate you have diabetes, your doctor may order additional tests to determine if you have MODY or another type of diabetes, such as type 1 or 2.

What do you need to know about MODY 2?

MODY 2. This article needs attention from an expert in Medicine. MODY 2 is a form of maturity onset diabetes of the young. MODY 2 is due to any of several mutations in the GCK gene on chromosome 7 for glucokinase.

How is MODY 2 related to type 2 diabetes?

If a parent has MODY 2 there is a 50% chance that a child will inherit the mutation and be at risk of developing diabetes at a young age. In adults distinguishing MODY 2 from early type 2 diabetes can be difficult. Features that make us suspect MODY 2 include A HbA1c that does not go over 7.8%

What kind of medication do you take for MODY 1?

MODY 1 and MODY 4. They’re usually treated with sulfonylureas, a type of diabetes medication. These drugs cause your pancreas to make more insulin. Some people with MODY 1 and MODY 4 may also need to take insulin. MODY 2.

What is the prognosis for patients with MODY 2?

Prognosis. Patients with MODY 2 have the best prognosis because it causes milder hyperglycemia. They typically do not require any medication, and do not develop long-term complications. Keeping blood sugar close to normal will minimize complications of MODY, as it does with other types of diabetes.