What is hydrolytic resistance glass?
Glass containers are classified according to their resistance to chemical attack, a test executed by heating the glass in contact with water for 30 min at 121 degrees C. The USP powdered glass test for glass containers was applied to different kinds of glasses used as containers for parenteral formulations.
Why is hydrolytic resistance test done?
A hydrolytic resistance test is performed on the glass to find out the limit of alkalinity liberated by it. According to the response of the glass containers to the resistance to the attack by the chemicals, glass containers are categorized.
What are the USP required tests for glass containers?
USP and IP provide two tests to determine the chemical resistance of glass containers. From the glass containers, alkaline constituents (oxides of sodium, potassium, calcium, aluminum, etc.)…
- Leakage test: Fill ten container with water.
- Collapsibility Test: This test applicable to containers.
Which test is done for USP Type I glass containers for injections?
1) Glass Containers for Pharmaceutical Use deal with the Glass Grains Test and the Surface Glass Test. The Glass Grains Test, combined with the Surface Glass Test for hydrolytic resistance, determines the type of glass being used in the packaging of pharmaceutical preparations.
What is the difference between Type 1 and Type 2 glass?
Type II glass generally has a lower melting point than Type I glass so it is much easier to mould. Type II glass containers are suitable for storing neutral aqueous preparations and acidic preparations whether they are parenteral or non-parenteral.
What is the meaning of hydrolytic?
adjective (Chem.), archaic Tending to remove or separate water; eliminating water. adjective (Chem.) of, pertaining to, or accompanied by hydrolysis . Nearly all of the digestive enzymes are hydrolytic in their action.
Which type of glass is used in parenterals?
In fact, borosilicate glass has been the primary packaging choice for parenteral products since its development more than 100 years ago due to its excellent barrier properties, chemical resistance, regulatory acceptance, and broad range of applications served.
What are qualities of an ideal container?
The three characteristics of highly effective containers
- Efficiency. One of the most prominent reasons to use a container is improved efficiency.
What is powder glass test?
A) POWDERED GLASS TEST : It is done to estimate the amount of alkali leached from the powdered glass which usually happens at the elevated temperatures. When the glass is powdered, leaching of alkali is enhanced, which can be titrated with 0.02N sulphuric acid using methyl red as an indicator .
Which type of glass is used for injectable?
Both Moulded and Tubular Type I borosilicate glass vials are suitable for a variety of pharmaceutical applications, including injectable preparations.
Which type of glass material has least hydrolytic resistance?
soda lime glass
Type IV glass containers (Type NP glass/General-purpose soda lime glass) This type of glass container has low hydrolytic resistance.
Which type of glass has least hydrolytic resistance?
Soda-lime glass – This type of glass is less chemically resistant than borosilicate glass and is typically suitable for storing dry powders and for containers for general sample storage applications. This glass type has only moderate hydrolytic resistance.