Why are hydrogels used in drug delivery?
Hydrogel delivery systems can leverage therapeutically beneficial outcomes of drug delivery and have found clinical use. Hydrogels can provide spatial and temporal control over the release of various therapeutic agents, including small-molecule drugs, macromolecular drugs and cells.
How do hydrogels work in drug delivery?
The swelling-controlled drug release from hydrogels uses drugs dispersed within a glassy polymer which when in contact with a bio-fluid begins swelling. The expansion during swelling occurs beyond its boundary facilitating the drug diffusion along with the polymer chain relaxation.
What is pulsatile drug delivery system?
Pulsatile drug delivery is defined as the rapid and transient release of certain amount of molecules within a short time period immediately after a predetermined off-released period, i.e., lag time, or these systems have a peculiar mechanism of delivering the drug rapidly and completely after a lag time, i.e., a period …
How do you classify hydrogels?
Based on the methods of preparation, hydrogels may be classified as homopolymer, copolymer, semi-interpenetrating network (semi-IPN) and interpenetrating network (IPN).
Why drug delivery is important?
Delivering drugs into the brain is critical to the successful treatment of certain diseases such as brain tumors, Alzheimer’s disease, and Parkinson’s disease, but better methods are needed to cross or bypass the BBB.
Why do we need drug delivery systems?
Drug delivery systems are engineered technologies for the targeted delivery and/or controlled release of therapeutic agents. Drugs have long been used to improve health and extend lives. Drug delivery systems control the rate at which a drug is released and the location in the body where it is released.
What is Rate controlled drug delivery system?
Introduction An ideal controlled drug delivery system is the one which delivers the drug at a predetermined rate, locally or systematically for a specified period of time 04/21/18 5. 6. Advantages Less fluctuation in drug blood levels. Frequency reduction in dosing. Improved patient convenience & compliance.
What are the advantages of hydrogels?
Advantages of Hydrogels The main advantage of hydrogel is that they possess a degree of flexibility very similar to natural tissue, due to their significant water content. They are biocompatible, biodegradable and can be injected. Hydrogels also possess good transport properties and easy to modify.
What are natural hydrogels?
Natural hydrogels include collagen, fibrin, hyaluronic acid, matrigel, and derivatives of natural materials such as chitosan, alginate and skill fibers. They remain the most physiological hydrogels as they are components of the extracellular matrix (ECM) in vivo.
How many types of hydrogels are there?
Smart wound-care materials Hydrogels are cross-linked polymeric networks swollen in biological fluid. They are widely used in drug delivery and tissue/organ repairs. Two types of hydrogels are usually available, i.e., sheet hydrogels and amorphous hydrogels.
Are there any drug delivery devices that use pulsatile?
Current research in the field of drug delivery devices, by which pulsed and/or pulsatile release is achieved, has been intensified. In this article several types of drug delivery systems using hydrogels are discussed that showed pulsed and/or pulsatile drug delivery characteristics.
When was Pulsatile Drug release control using hydrogels?
Advanced Drug Delivery Reviews Volume 54, Issue 1, 17 January 2002, Pages 53-77 Pulsatile drug release control using hydrogels Author links open overlay panelAkihikoKikuchiTeruoOkano Show more Share Cite https://doi.org/10.1016/S0169-409X(01)00243-5Get rights and content Abstract
Why are hydrogels used for drug loading and release?
Hydrogels: swelling, drug loading, and release Hydrogels have been used by many investigators in controlled-release drug delivery systems because of their good tissue compatibility and easy manipulation of swelling level and, thereby, solute permeability. The desired kinetics, duration, and rate of solute release from hydrogels are limited to sp …
What is the definition of a Pulsatile Drug release?
Pulsed or pulsatile drug release is defined as the the rapid and transient release of a certain amount of drug molecules within a short time-period immediately after a predetermined off-release period.