What is the difference between dengue IgG and IgM?
IgG as a sero-marker of Dengue infection. If the IgG is positive but the IgM is low or negative, then it is likely that the patient had an infection sometime in the past. Presence of IgG alone (absence of NS1 Ag and/or IgM), does not indicate active dengue infection.
How long does dengue IgM stay positive?
As the immune system fights the infection, IgM antibodies against dengue virus are detectable starting 4-5 days after onset of symptoms and are reliably detectable for approximately 12 weeks.
What is dengue IgG and IgM positive?
Positive IgM and IgG tests for dengue antibodies detected in an initial blood sample mean that it is likely that the person became infected with dengue virus within recent weeks. IgM antibody tests can be positive if a person has been infected with a similar virus, such as chikungunya (called cross-reaction).
What is NS1 in dengue?
Positive: The presence of dengue nonstructural protein 1 (NS1) antigen is consistent with acute-phase infection with dengue virus. The NS1 antigen is typically detectable within 1 to 2 days following infection and up to 9 days following symptom onset.
How is dengue IgM treated?
There is no specific medicine to treat dengue infection. If you think you may have dengue fever, you should use pain relievers with acetaminophen and avoid medicines with aspirin, which could worsen bleeding. You should also rest, drink plenty of fluids, and see your doctor.
What is IgG positive and IgM negative?
IgG is Positive and IgM is Negative The subject’s immune system has produced antibodies to the target viral antigen. The subject is likely in the later stages of the disease course but may still be contagious to others and capable of spreading the virus.
How do you treat dengue NS1 positive?
Most cases of dengue can be treated at home if detected early. The NS1 antigen test is the most effective for early diagnosis of dengue infection. The main focus of treatment is to ensure that the patient gets adequate hydration. Acetaminophen (paracetamol) is used to manage the fever.
What happens if dengue NS1 is positive?
A positive NS1 test result confirms dengue virus infection without providing serotype information. A negative NS1 test result does not rule out infection. People with negative NS1 results should be tested for the presence of dengue IgM antibodies to determine possible recent dengue exposure.
What is dengue IgG IgM?
Positive IgM and IgG tests for dengue antibodies detected in an initial blood sample mean that it is likely that the person became infected with dengue virus within recent weeks. If the IgG is positive but the IgM is low or negative, then it is likely that the person had an infection sometime in the past.
How dengue is treated in hospital?
Dengue Treatment Blood pressure monitoring. Supportive care in a hospital. IV fluid and electrolyte replacement. Transfusion to replace blood loss.
What is dengue IgG positive IgM negative?
When do dengue antibodies come positive for NS1?
Dengue Fever Antibodies (IgG, IgM) and NS1 Antigen Panel – NS1 antigen detection can serve as an effective bridge between dengue RNA detection (usually negative by day 5) and dengue IgM detection (may not be positive until day 6) for identifying acute dengue virus infection.
What does the NS1, IgG and IgM test measure?
The dengue antigen NS1, IgG & IgM test measures the dengue virus or antibodies which are produced in response to dengue infection. Dengue fever is a viral infection which is transmitted to humans by mosquitoes which live in tropical and subtropical climates and are responsible for carrying the virus.
What does a positive IgM test mean for dengue?
Positive IgM: Patients with a positive IgM test result are classified as presumptive, recent dengue virus infections. Patients with negative IgM results before day 8 of illness and absent or negative NAAT or NS1 results are considered unconfirmed cases.
How is MAC-ELISA used to diagnose dengue?
The MAC-ELISA is based on capturing human IgM antibodies on a microtiter plate using anti-human-IgM antibody followed by the addition of dengue virus antigens. The antigens used for this assay are derived from the envelope proteins of the four dengue virus serotypes (DENV-1-4). How should it be used and at what time during infection?