What is rhBMP?

What is rhBMP?

rhBMP-2 is a disulfide-linked dimeric protein molecule with two major subunit species of 114 and 131 amino acids. Each subunit is glycosylated at one site with high-mannose-type glycans. rhBMP-2 is produced by a genetically engineered Chinese hamster ovary cell line. rhBMP-2 and excipients are lyophilized.

How much does Infuse bone graft cost?

This procedure minimizes injury to the back muscles and nerves. While this synthetic bone graft technology is a significant advance in medicine, it also comes with a hefty price tag. Using BMPs adds several thousand dollars to the average cost of spinal surgery. Packages of Infuse can range from $2,500 to $5,000.

Why is Osteoconductivity important in a bone graft?

Osteoconduction is the ability of bone-forming cells in the grafting area to move across a scaffold and slowly replace it with new bone over time. Osteoconductive materials serve as a scaffold onto which bone cells (osteoblasts and osteoclasts) can attach, migrate, grow and/or divide.

What is Infuse bone graft?

Infuse™ Bone Graft is the premium product for autograft replacement* due to its high osteoinductivity. Infuse bone graft is recombinant human bone morphogenetic protein-2 (rhBMP-2) applied to an absorbable collagen sponge carrier (ACS). One of the functions of the protein is to stimulate natural bone formation.

Is BMP FDA approved?

Although 20 different BMPs have been discovered, only BMP-2 is currently FDA approved and available in recombinant form for use in human spine surgery. BMP-7, or OP-1, was previously given a Humanitarian Device Exemption and ultimately was not approved by the FDA.

Is BMP-2 a growth factor?

Bone morphogenetic proteins (BMPs) are multi-functional growth factors that belong to the transforming growth factor beta (TGFbeta) superfamily. The roles of BMPs in embryonic development and cellular functions in postnatal and adult animals have been extensively studied in recent years.

Is bone grafting painful?

Most patients who receive bone grafts are completely pain-free and do just fine as long as they take the antibiotics. Your dentist also has to wait for the bone graft to fuse with the natural bones that are already in your mouth.

How long does a bone graft take to heal?

The Recovery Time after the Procedure Your recovery may require two weeks to 3 months but the bone graft itself will require three months to heal. However, you will be advised not to indulge in extensive exercises for at least six months and to keep the area of the bone graft clean and dry.

How is Osteoconductivity measured?

For determining the osteoconductivity, the surface length of the single BSM granules and also the length of the BSM-bone-contact were measured. Afterwards, the osteoconductivity was calculated by forming the quotient of the total contact area and the total granule surface length.

What is the difference between osteogenesis and Osteoinduction?

Osteoinduction is the process by which osteogenesis is induced. It is a phenomenon regularly seen in any type of bone healing process. Osteoinduction implies the recruitment of immature cells and the stimulation of these cells to develop into preosteoblasts. Osteoconduction means that bone grows on a surface.

What is infuse used for?

Infuse has been on the market since 2002 and has been used in more than 1 million patients worldwide. Infuse is indicated for certain spinal fusion procedures in skeletally mature patients with degenerative disc disease (DDD) from L2 to S1, as well as for treating certain acute, open tibial shaft fractures.

Is infuse still on the market?

In the U.S., off-label marketing and injury complaints triggered seven government investigations of Infuse, more than 7,000 patient lawsuits and nearly a half-billion dollars in legal settlements. Despite the controversy, the product has remained on the market, even as studies show its use is predominantly off-label.

What does rhBMP-2 stand for?

BMP Bone Grafting (Bone Morphogenetic Protein) The active ingredient in INFUSE Bone Graft — rhBMP-2 — is a manufactured version of a protein already present in the body that promotes new bone growth.

Where is rhBMP-2 placed in the body?

BMP Surgery Procedure. In instances of jaw bone resorption, rhBMP-2 may be placed in the section(s) of the jaw bone that needs to be built back up in preparation for dental implants. To learn more about INFUSE Bone Graft, please contact Dr. Shroyer’s office.

What is rhBMP-2 bone grafting?

BMP Bone Grafting (Bone Morphogenetic Protein) Certain BMPs have been studied for many years because of their ability to heal bone and eliminate the need for bone graft harvesting from other parts of the body. rhBMP-2 has been studied more than any other BMP and is FDA approved for use in certain spinal, tibial and oral surgeries.

How can rhBMP-2 be used for jaw bone resorption?

In instances of jaw bone resorption, rhBMP-2 may be placed in the section or sections of the jaw bone that need to be built back up in preparation for dental implants. Infuse Bone Graft stimulates the recruitment and differentiation of bone-forming cells inducing new bone formation or healing existing bone.