How does sodium zirconium Cyclosilicate corrects hyperkalemia?
Thus, there is a need for additional agents that can safely treat hyperkalemia in both patients with acute disease and those with chronic disease. Sodium zirconium cyclosilicate (ZS-9) is a highly selective cation exchanger that entraps potassium in the intestinal tract in exchange for sodium and hydrogen (Fig.
How does sodium zirconium Cyclosilicate work?
Sodium zirconium cyclosilicate is in a class of medications called potassium removing agents. It works by removing excess potassium from the body.
What is sodium zirconium Cyclosilicate used for?
Sodium zirconium cyclosilicate is used to treat hyperkalemia (high levels of potassium in the blood) in adults. Sodium zirconium cyclosilicate works directly in the intestines and is not absorbed into your bloodstream. Sodium zirconium cyclosilicate may also be used for purposes not listed in this medication guide.
How is Lokelma administered?
2.1 Dosage Administer LOKELMA orally as a suspension in water [see Dosage and Administration (2.2)]. For continued treatment, the recommended dose is 10 g once daily. Monitor serum potassium and adjust the dose of LOKELMA based on the serum potassium level and desired target range.
How do you fix hyperkalemia?
Patients with hyperkalemia who have electrocardiographic (ECG) changes, a rapid rate of rise of serum potassium, decreased renal function, or significant acidosis should be urgently treated. Patients with hyperkalemia and characteristic ECG changes should be given intravenous calcium gluconate.
What are the side effects of Kayexalate?
Common side effects of Kayexalate include:
- loss of appetite,
- upset stomach,
- nausea,
- vomiting,
- constipation, or.
- diarrhea.
Does Lokelma make you poop?
Constipation was not a reported side effect of Lokelma in clinical trials. However, other drugs used to treat hyperkalemia in adults can cause constipation.
What is the treatment of hyperkalemia?
Medications Used in Acute Treatment of Hyperkalemia
| Medication* | Dosage |
|---|---|
| Calcium gluconate | 10 to 20 mL of 10 percent solution IV over two to three minutes |
| Insulin | Regular insulin 10 units IV with 50 mL of 50 percent glucose |
| Albuterol (Ventolin) | 10 to 20 mg by nebulizer over 10 minutes (use concentrated form, 5 mg per mL) |
When do you treat high potassium?
You will need emergency treatment if your potassium level is very high, or if you have danger signs, such as changes in your ECG. Emergency treatment may include: Calcium given into your veins (IV) to treat the muscle and heart effects of high potassium levels.
How does the body get rid of excess potassium?
Your kidneys filter potassium from the foods and drinks you consume. Your body gets rid of excess potassium when you pee. With hyperkalemia, your body has too much potassium for your kidneys to remove. As a result, potassium builds up in your blood.
Does KAYEXALATE cause loose stools?
SIDE EFFECTS: Loss of appetite, nausea, vomiting, or constipation may occur. Diarrhea may occur less frequently.
How is Sodium zirconium cyclosilicate used to treat hyperkalemia?
We investigated whether sodium zirconium cyclosilicate (ZS-9), a novel selective cation exchanger, could lower serum potassium levels in patients with hyperkalemia. Methods In this multicenter, two-stage, double-blind, phase 3 trial, we randomly assigned 753 patients with hyperkalemia to receive either ZS-9 (at a dose of 1.25 g, 2.5 g, 5 g,
Where does sodium zirconium cyclosilicate go in the body?
Sodium zirconium cyclosilicate (ZS-9) is a highly selective cation exchanger that entraps potassium in the intestinal tract in exchange for sodium and hydrogen (Fig.
What kind of cation exchanger is Sodium zirconium cyclosilicate?
Sodium zirconium cyclosilicate (ZS-9) is a highly selective cation exchanger that entraps potassium in the intestinal tract in exchange for sodium and hydrogen (Fig. S1 in the Supplementary Appendix, available with the full text of this article at NEJM.org). 16 In a phase 2 study, ZS-9, as compared with placebo,…
How is Sodium zirconium cyclosilicate similar to Kayexalate?
Sodium Zirconium Cyclosilicate (SZC) is a potassium-exchange resin similar in concept to sodium polystyrene sulfonate (Kayexalate). It’s not particularly new, as the original studies were performed around 2015. Accumulating evidence over the last five years supports the drug’s safety.