Can cisatracurium cause seizures?
Laudanosine is a metabolite of the neuromuscular-blocking drugs atracurium and cisatracurium with potentially toxic systemic effects. It crosses the blood-brain barrier and may cause excitement and seizure activity.
What is the use of atracurium?
Atracurium Besilate Injection is indicated as an adjunct to general anaesthesia during surgery to relax skeletal muscles, and to facilitate endotracheal intubation and mechanical ventilation. It is also indicated to facilitate mechanical ventilation in intensive care unit (ICU) patients.
What is the antidote for atracurium?
Once evidence of spontaneous recovery is present, the neuromuscular block produced by atracurium besilate can be rapidly reversed by standard doses of anticholinesterase agents, such as neostigmine and edrophonium, accompanied or preceded by atropine or glycopyrrolate, with no evidence of recurarisation.
What is the reversal agent for Cisatracurium?
Cisatracurium binds to cholinergic receptors on the motor end-plate to antagonise the action of acetylcholine, resulting in a competitive block of neuromuscular transmission. This action is readily reversed by anti-cholinesterase agents such as neostigmine or edrophonium.
How long can you stay on nimbex?
When administered during stable opioid/nitrous oxide/oxygen anesthesia, 0.15 mg/kg NIMBEX produced maximum neuromuscular blockade in an average of about 3 minutes (range: 1.5 to 8 minutes) with a clinically effective block for 36 minutes (range: 29 to 46 minutes) [see Clinical Studies].
What is the action of vecuronium?
Mechanism of Action Vecuronium is a nondepolarizing agent that achieves its skeletal muscle paralysis by competing with acetylcholine for cholinergic receptor sites and binding with the nicotinic cholinergic receptor at the postjunctional membrane.
What is the antidote of succinylcholine?
Dantrolene is an effective antidote.
How do you reverse vecuronium?
Sugammadex, a selective relaxant binding agent, reverses the effects of rocuronium and vecuronium by encapsulation. This study assessed the efficacy of sugammadex compared with neostigmine in reversal of profound vecuronium-induced neuromuscular block under sevoflurane anesthesia.
When do you reverse neuromuscular blockade?
Residual neuromuscular blockade It should always be reversed to prevent diplopia, laryngeal weakness, atelectasis, CO2 retention and respiratory acidosis.