Who discovered cimetidine?

Sir James W. Black
Sir James W. Black shared the 1988 Nobel Prize in Physiology or Medicine for the discovery of propranolol and also is credited for the discovery of cimetidine. At the time (1964), histamine was known to stimulate the secretion of stomach acid, but also that traditional antihistamines had no effect on acid production.

What is the primary action of cimetidine?

Cimetidine belongs to a class of drugs commonly called H2 blockers. It works by reducing the amount of acid in your stomach. This medication is also available without a prescription. It is used to treat occasional heartburn caused by too much acid in the stomach (also called acid indigestion or sour stomach).

What chemical is in cimetidine?

Cimetidine is a member of the class of guanidines that consists of guanidine carrying a methyl substituent at position 1, a cyano group at position 2 and a 2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl group at position 3. It is a H2-receptor antagonist that inhibits the production of acid in stomach.

Who developed Tagamet?

James Black
James Black dies at 85; Nobel laureate developed Inderal and Tagamet. Dr. James Black, a Scottish Nobel laureate who pioneered the rational design of drugs and, in the process, developed the first widely used drugs for treating heart disease and blocking stomach acid production, died Monday. He was 85.

Are cimetidine and omeprazole the same?

Omeprazole is more effective than cimetidine for the relief of all grades of gastro-oesophageal reflux disease-associated heartburn, irrespective of the presence or absence of endoscopic oesophagitis. Aliment Pharmacol Ther.

Has cimetidine been discontinued?

Determination That TAGAMET (Cimetidine) Tablets and Other Drug Products Were Not Withdrawn From Sale for Reasons of Safety or Effectiveness.

What does cimetidine cure?

Cimetidine is used to treat ulcers; gastroesophageal reflux disease (GERD), a condition in which backward flow of acid from the stomach causes heartburn and injury of the food pipe (esophagus); and conditions where the stomach produces too much acid, such as Zollinger-Ellison syndrome.

Does cimetidine raise blood pressure?

Intracerebroventricular administration of cimetidine or metiamide (2 mumol/rat) increased the blood pressure and heart rate. It is concluded that the hypotension after i.v. cimetidine is mediated by peripheral mechanisms.

Is cimetidine an antacid?

Cimetidine is in a group of medications called histamine type-2-receptor antagonists that block the release of histamine which triggers the secretion of stomach acid. This prevents the indigestion symptoms. Antacids work by neutralizing the stomach acid that is already present.

Why was Tagamet taken off the market?

FDA seeks withdrawal of heartburn drugs due to new carcinogen concerns. As far as other heartburn medicines, FDA says that its testing has not found NDMA in famotidine (Pepcid), cimetidine (Tagamet), esomeprazole (Nexium), lansoprazole (Prevacid) or omeprazole (Prilosec).

Is Tagamet still on the market?

Tagamet® is available over-the-counter at drug, grocery, and mass retailers nationwide.

Which is safer cimetidine or omeprazole?

Omeprazole is more effective than cimetidine in the prevention of recurrence of GERD-associated heartburn and the occurrence of underlying oesophagitis.