What is Chronotropy vs Inotropy?

What is Chronotropy vs Inotropy?

Stimulation of the Beta1-adrenergic receptors in the heart results in positive inotropic (increases contractility), chronotropic (increases heart rate), dromotropic (increases rate of conduction through AV node) and lusitropic (increases relaxation of myocardium during diastole) effects.

What do you mean by dromotropic?

The term dromotropic derives from the Greek word δρόμος drómos, meaning “running”, a course, a race. A dromotropic agent is one which affects the conduction speed (in fact the magnitude of delay) in the AV node, and subsequently the rate of electrical impulses in the heart.

What are some dromotropic drugs?


  • Bilirubin.
  • Bile.
  • Verapamil.
  • Anesthetics.
  • Diltiazem.
  • Chronotropic.
  • Dermatitis.
  • Atrial Fibrillation.

How do you remember inotropic chronotropic dromotropic?

As mentioned, these can be remembered by the mnemonic: I Know! Sax 5th Avenue. If asked, there are actually five major classifications of your inotropic, chronotropic, and dromotropic drugs (A, B, C, D, and E). You can remember that because of the “5th” in your mnemonic.

Is digoxin a positive Dromotropic?

Finally, digoxin has a negative dromotropic effect on the atrioventricular node, leading to an increase in refractory periods and nodal conduction time.

Is dopamine and dobutamine the same thing?

Dopamine is typically used in the treatment of septic shock or cardiogenic shock. Dobutamine is a drug that primarily stimulates beta-1 receptors, leading to increased inotropic and chronotropic effects. to al lesser extent, dobutamine also stimulates beta-2 adrenergic receptors, leading to vasodilatation.

What is the inotropic state of the heart?

Positively inotropic agents increase the strength of muscular contraction. The term inotropic state is most commonly used in reference to various drugs that affect the strength of contraction of heart muscle (myocardial contractility). However, it can also refer to pathological conditions.

What is difference between dopamine and dobutamine?

What are inotropic effects?

An inotrope is an agent that alters the force or energy of muscular contractions. Negatively inotropic agents weaken the force of muscular contractions. Positively inotropic agents increase the strength of muscular contraction.

Is digoxin a negative Dromotropic?

Is digoxin an inotropic drug?

Digoxin is one of the positive inotropic agents which improves hemodynamics and does not have a deteriorating effect on blood pressure or heart rate [9].

Does dobutamine increase BP?

Dobutamine may cause a marked increase in heart rate or blood pressure, especially systolic pressure. Approximately 10% of patients in clinical studies have had rate increases of 30 beats/minute or more, and about 7.5% have had a 50 mm Hg or greater increase in systolic pressure.