What is the drug mexiletine used for?
Mexiletine is used to treat certain types of ventricular arrhythmias (abnormal heart rhythms). Mexiletine is in a class of medications called antiarrhythmics. It works by blocking certain electrical signals in the heart to stabilize the heart rhythm.
What is Nadolol used to treat?
Nadolol is used alone or in combination with other medications to treat high blood pressure. It is also used to prevent angina (chest pain).
What is the side effect of sotalol?
The main side effects of sotalol are feeling dizzy or sick, feeling tired, having diarrhoea or a headache – these are usually mild and short-lived. You’re more likely to have side effects if you’re on a very high dose of sotalol.
Does mexitil lower heart rate?
Mexiletine is known as an anti-arrhythmic drug. It works by blocking certain electrical signals in the heart that can cause an irregular heartbeat. Treating an irregular heartbeat can decrease the risk for blood clots, and this effect can reduce your risk of heart attack or stroke.
Why was mexiletine discontinued?
However, mexiletine treatment had to be discontinued permanently in 8 of 92 patients (9%) because of intolerable side effects. We conclude that the added efficacy and possible improved arrhythmia-free survival associated with combining mexiletine with a class Ia agent should be further investigated.
Does mexiletine cause weight gain?
Conclusions: Mexiletine may affect body weight regulation. It ameliorated the metabolic parameters possibly by decreasing visceral fat. Further study should be performed to clarify the mechanism of the effect.
What is the best time to take nadolol?
Nadolol (Corgard) may make you feel tired or dizzy when you first start taking it, so taking it before bedtime can help you sleep through it. If you don’t have side effects, you can take it at any time of day, though it works best if you take it around the same time each day.
What are side effects of nadolol?
Side Effects
- Blurred vision.
- chest pain or discomfort.
- dilated neck veins.
- dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly.
- extreme fatigue.
- irregular breathing.
- lightheadedness, dizziness, or fainting.
- paleness or cold feeling in fingertips and toes.
Is sotalol a high risk medication?
Sotalol can cause life threatening ventricular tachycardia associated with QT interval prolongation.
Does Mexiletine affect heart rate?
Mexiletine belongs to the group of medicines known as antiarrhythmics. It is used to correct irregular heartbeats to a normal rhythm. Mexiletine produces its helpful effects by slowing nerve impulses in the heart and making the heart tissue less sensitive.
How long does it take for Mexiletine to get out of your system?
Unlike lidocaine, its first-pass metabolism is low. Peak blood levels are reached in two to three hours. In normal subjects, the plasma elimination half-life of Mexiletine is approximately 10 to12 hours.