Why does meningitis cause SIADH?

Why does meningitis cause SIADH?

SIADH tends to occur in people with heart failure or with a brain injury that affects the hypothalamus. The hypothalamus is the part of the brain that works with the pituitary gland to make hormones. Other causes may include: Inflammation of the membranes that cover the brain and spinal cord (meningitis)

What is SIADH in meningitis?

In patients with meningitis, fluid restriction is recommended to counter the syndrome of inappropriate secretion of antidiuretic hormone (SIADH) and to reduce cerebral oedema. However, any effects of an increased plasma level of ADH upon cerebral oedema would be due not to fluid retention but to hypoosmolality.

What are some complications of SIADH?

Complications of SIADH depend on how low blood sodium levels are….Complications

  • Headaches.
  • Depression.
  • Memory problems.
  • Muscle cramps.
  • Tremors.

What is the most serious complication of SIADH?

A low sodium level or hyponatremia is a major complication of SIADH and is responsible for many of the symptoms of SIADH. Early symptoms may be mild and include cramping, nausea, and vomiting. In severe cases, SIADH can cause confusion, seizures, and coma.

Does SIADH cause increased urine output?

In SIADH, hyponatremia is caused by water retention due to inappropriate secretion of antidiuretic hormone (ADH) (10-15). But in CSWS, hyponatremia is associated with high urine output, high urine sodium concentration, and plasma volume depletion (16).

Why is sodium low in meningitis?

The aetiological mechanism of hyponatraemia in bacterial meningitis is unclear. It may result from the syndrome of inappropriate anti-diuretic hormone secretion (SIADH), the cerebral salt wasting (CSW) syndrome, or aggressive fluid resuscitation.

What is happening in SIADH?

Syndrome of inappropriate antidiuretic hormone secretion (SIADH) is a condition in which the body makes too much antidiuretic hormone (ADH). This hormone helps the kidneys control the amount of water your body loses through the urine. SIADH causes the body to retain too much water.

Is SIADH fatal?

It lowers the amount of urine the body makes and increases the amount of water the kidneys take up. Too much ADH leads to water retention, electrolyte imbalances and a low level of sodium in the blood (called hyponatremia or water intoxication). SIADH that develops suddenly can be life-threatening.

Why does SIADH cause pneumonia?

The pathogenesis for the development of SIADH in COVID-19 pneumonia per preliminary reports is due to the production of certain proinflammatory cytokines, particularly, IL-6.

Is SIADH life threatening?