How effective is metronomic chemotherapy?
[9] Overall, metronomic chemotherapy offers a significant clinical improvement including improvement in quality of life with minimal toxicity. However, data are still not adequate to draw definitive conclusions regarding the tolerance of these drug combinations.
What is metronomic dosing?
Listen to pronunciation. (MEH-truh-NAH-mik KEE-moh-THAYR-uh-pee) Treatment in which low doses of anticancer drugs are given on a continuous or frequent, regular schedule (such as daily or weekly), usually over a long time.
What is palliative chemotherapy?
Palliative chemotherapy is treatment that is given in the non-curative setting to optimize symptom control, improve or maintain QoL and, ideally, to also improve survival.
What is metronomic cyclophosphamide?
Metronomic chemotherapy is the chronic administration of low, equally spaced, doses of antineoplastic drugs with therapeutic efficacy and low toxicity. Oral metronomic cyclophosphamide has gained increasing interest in recent years in the treatment of patients with recurrent ovarian cancer.
What do they do in chemotherapy?
Chemotherapy is a drug treatment that uses powerful chemicals to kill fast-growing cells in your body. Chemotherapy is most often used to treat cancer, since cancer cells grow and multiply much more quickly than most cells in the body. Many different chemotherapy drugs are available.
What cadence means?
1a : a rhythmic sequence or flow of sounds in language the grand cadence of his poetry. b : the beat, time, or measure of rhythmical motion or activity The drill sergeant counted cadence.
Are there any trials for low dose metronomic chemotherapy?
Low-dose metronomic (LDM) chemotherapy, the frequent and continuous use of low doses of conventional chemotherapeutics, is an emerging alternative to conventional chemotherapy. While promising tumour control rates and excellent safety profiles have been observed, there are no definitive phase III tr …
What are the main characteristics of metronomic chemotherapy?
Metronomic chemotherapy is the frequent administration of chemotherapy drugs at doses below the MTD and with no prolonged drug-free break. It thus achieves a sustained low blood level of the drug without significant toxic side-effects.[8] The main characteristics of metronomic chemotherapy are:[9]
How is a bolus dose used in chemotherapy?
Conventional chemotherapy In conventional chemotherapy, a dose close to the maximum tolerated dose is administered in a bolus manner to achieve cytotoxic effects on tumor cells.
How is metronomic therapy used to treat lung cancer?
Metronomic therapy was discovered to be effective in treatment of lung cancer as well, especially in metastatic non-small-cell lung carcinoma (NSCLC). There are a variety of drugs used for cancer treatment. Vinorelbine is one of the drugs that are used for cancer treatment.