Is atorvastatin safe in renal failure?

Conclusion: Although the medication caused no severe adverse events, we recommend caution when using atorvastatin for severe CKD patients until further evidence of its safety and efficacy is verified.

Is atorvastatin contraindicated in renal failure?

For statins, the acceptable dosage varies according to the statin used and the level of kidney function. In general, statins that are not metabolized by the kidney are well tolerated at all doses. Indeed, doses of atorvastatin of up to 80 mg/day produced no serious adverse events in hemodialysis patients.

Does atorvastatin need renal adjustment?

Renal disease does not affect the plasma concentrations or the LDL-C reduction of LIPITOR; thus, dosage adjustment in patients with renal dysfunction is not necessary [see Warnings and Precautions (5.1) and Clinical Pharmacology (12.3)].

Which statin is safest in renal failure?

Although effect estimates and rankings of individual treatments were variable across the analyses, in general atorvastatin 40–80 mg, fluvastatin 20 mg/ezetimibe 10 mg, pravastatin 10–20 mg, simvastatin 10–40 mg, and fluvastatin 20 mg were the most effective treatments with regard to eGFR decline.

Is statin bad for kidneys?

Very rarely, statins can cause life-threatening muscle damage called rhabdomyolysis (rab-doe-my-OL-ih-sis). Rhabdomyolysis can cause severe muscle pain, liver damage, kidney failure and death. The risk of very serious side effects is extremely low, and calculated in a few cases per million people taking statins.

Does atorvastatin increase creatinine?

Renal function was examined in this study using Cockcroft-Gault derived creatinine clearance (CrCl) values. The mean CrCl at entry was 77 ml/min. Patients on atorvastatin showed a 12% rise in CrCl, patients on other statins a 4.9% rise in CrCl, and statin free patients a 5.2% fall in CrCl over 36 months of follow up.

Is it safe to take 80 mg of atorvastatin?

Atorvastatin has been shown to reduce coronary events and revascularization procedures in patients with multiple risk factors for coronary heart disease. Recent studies with atorvastatin 80 mg support the overall safety of this dose during long-term treatment.

Is atorvastatin hard on kidneys?

Another study showed that high-dose statins were 34 percent more likely to cause kidney damage in the first 120 days of treatment, but it’s also possible that statins at lower doses may not cause such side effects. More research is still needed, particularly studies that focus on people with kidney disease.

When should atorvastatin 80 mg be taken?

Take atorvastatin once a day. You can choose to take it at any time, as long as you stick to the same time every day. Sometimes doctors may recommend taking it in the evening. This is because your body makes most cholesterol at night.

What should you not take with atorvastatin?

While taking atorvastatin (Lipitor), avoid high-fat and high-cholesterol foods as part of your overall treatment. You should avoid large quantities of grapefruit or grapefruit juice, which can increase the risk of serious side effects. Also, avoid excess alcohol use, as this may cause serious liver problems.

What is the normal dosage for atorvastatin?

Atorvastatin Dosing. When using the medication to treat high cholesterol, dosing guidelines generally call for a starting dosage of atorvastatin 10 mg or 20 mg a day. The average dose for people with high cholesterol ranges from 20 mg to 40 mg a day.

How effective is atorvastatin?

The dose can be gradually increased until the desired effect. Atorvastatin can reduce LDL levels by up to 45-60%. Atorvastatin 40-80 mg is considered a high intensity statin per the American College of Cardiology and American Heart Association.

Can atorvastatin cause kidney disease?

Atorvastatin can cause a condition that results in the breakdown of skeletal muscle tissue, potentially leading to kidney failure. This condition may be more likely to occur in older adults and in people who have kidney disease or poorly controlled hypothyroidism (underactive thyroid).