Which of the following is a side effects of clofazimine?

Which of the following is a side effects of clofazimine?

COMMON side effects

  • discoloration of the eyelid.
  • tear discoloration.
  • irritation of the stomach or intestines.
  • itching.
  • discolored sweat.
  • a skin rash.
  • decreased appetite.
  • sputum discoloration.

Does dapsone cause bone marrow suppression?

Agranulocytosis is an adverse effect of dapsone manifested as bone marrow suppression, which is caused by the formation of antibodies against neutrophil progenitor cells, decreasing the granulocyte formation.

What are anti Leprotic drugs?

The drugs used in WHO-MDT are a combination of rifampicin, clofazimine and dapsonefor MB leprosy patients and rifampicin and dapsone for PB leprosy patients. Among these drugs, rifampicin is the most important anti-leprosy drug and therefore, is included in the treatment of both types of leprosy.

What is the rationale for MDT in leprosy treatment?

Leprosy has been considered a curable disease after the implementation of multidrug therapy (MDT), which has been proven to be safe and effective, by bringing about a significant change in the global and national scenario of leprosy by upgrading the control of leprosy to the next stage of eradication.

What is the full form of MDT?

MDT – Mountain Daylight Time.

What are side effects of moxifloxacin?

Moxifloxacin may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • nausea.
  • vomiting.
  • stomach pain.
  • diarrhea.
  • constipation.
  • heartburn.

Is dapsone bad for your liver?

Dapsone induced liver injury can result in acute liver failure, but most cases resolve rapidly with discontinuation of drug and full recovery is expected within 2 to 8 weeks. Severe cholestatic injury may be prolonged.

Can penicillin cure leprosy?

Doctors recommend long-term treatment, usually for 6 months to a year. If you have severe leprosy, you may need to take antibiotics longer. Antibiotics can’t treat the nerve damage that comes with leprosy.

Does dapsone make you tired?

Seek immediate medical attention if you develop signs of an infection (e.g., fever, chills, persistent sore throat), easy bruising/bleeding, unusual tiredness, pale skin, yellowing eyes/skin, dark urine, stomach/abdominal pain. Dapsone can commonly cause a rash that is usually not serious.

Is the who MDT for leprosy treatment effective in Brazil?

The WHO MDT for leprosy treatment was officially introduced in Brazil in 1991 and comprises three drugs: dapsone, rifampicin and clofazimine. There are few good studies on the frequency of side-effects attributable to MDT in Brazil. A retrospective and descriptive study carried out in a LCP in Vitória, State of Espirito Santo, Brazil.

Does clofazimine have any effect on MB leprosy?

It is possible that this is attributable to the anti-inflammatory effect of clofazimine. On the other hand, there seems to be a higher reporting of reversal reactions (Type I) in MB leprosy patients in the first year of MDT which then gradually declines.

Does MDT expose patients to a higher risk of serious side-effects?

Does MDT expose patients to a higher risk of serious side-effects? When more than one drug is used, naturally there is a risk of side-effects from each of the drugs used in the combination.