Does insulin inhibit HMG-CoA synthase?

HMG-CoA synthase promoter activity is regulated by insulin or EGF.

Which of the following would be a contraindication to taking a HMG-CoA reductase inhibitor?

HMG-CoA reductase inhibitors (statins) Examples include Atorvastatin, fluvastatin, lovastatin, pitavastatin, pravastatin, rosuvastatin, simvastatin. Contraindications include hypersensitivity, active liver disease, pregnancy, lactation, coadministration with strong CYP3A4 inhibitors (selected statins)

What activates HMG-CoA reductase?

Regulation of HMG-CoA Reductase First by regulation of transcription of the reductase gene, which is activated by sterol regulatory element binding protein, a protein that binds to the promoter of the HMGR gene when cholesterol levels fall.

What happens if HMG-CoA reductase is inhibited?

Inhibition of HMG-CoA reductase, a rate-limiting enzyme in hepatic cholesterol synthesis by statins, results in the reduction of intracellular cholesterol content that in turn induces an increase in SREBP-2-mediated hepatic LDL receptor synthesis (Sahebkar and Watts, 2013b) (Chapter 11).

Where is HMG-CoA found?

HMG-CoA reductase is anchored in the membrane of the endoplasmic reticulum, and was long regarded as having seven transmembrane domains, with the active site located in a long carboxyl terminal domain in the cytosol.

How do the HMG-CoA reductase inhibitors work?

β-Hydroxy β-methylglutaryl-CoA (HMG-CoA) reductase inhibitors, more popularly known as statins, work by reducing the cholesterol levels in the body. HMG-CoA inhibitors interfere with the ability of the body to build cholesterol from dietary fat.

What is the role of HMG-CoA?

HMG-CoA is the precursor for cholesterol synthesis. HMG-CoA is formed by condensation of acetyl-CoA and acetoacetyl-CoA, catalyzed by HMG-CoA synthase. HMG-CoA reductase catalyzes the production of mevalonate from HMG-CoA, in which the HMG-CoA reductase reaction is the rate-limiting step for cholesterol synthesis.

What is a common side effect of HMG-CoA reductase inhibitors?

The most common side effects of HMG-CoA reductase inhibitors include: Muscle aches, tenderness, or weakness (myalgia) Drowsiness. Dizziness.

What is the most serious side effect of all HMG-CoA reductase inhibitors?

Musculoskeletal: Myalgia is the most common side effect of statins, and 1 to 10% of individuals using statins have myalgias. Myositis is less common and characteristically presents by an increase in creatine kinase (CK).