Which type of drugs can be titrated diazotization titration?

It is used determination of alpha drug , sulphanilamide, chlorophenol, procaine etc.

What is the suitable temperature required for diazotization titration?

Diazotization is usually carried out at low temperatures between 0 – 5 °C. We have to maintain low temperatures because if the temperature is above 5 °C, diazonium salts which are in aqueous solution tend to decompose explosively.

What is Diazotisation mechanism?

What is Diazotization? The chemical process used in converting a primary aromatic amine into the corresponding diazonium salt of the amine is commonly referred to as diazotization. This process is also known as ‘diazotization’.

What is sodium nitrite titration?

The titration may be carried out manually or by means of an automatic titrator. In the manual titration, add 0.1 M sodium nitrite slowly and when the titration is within 1 ml of the endpoint, add the titrant in 0.1 ml portions, allowing not less than 1 minute between additions.

What is the principle of diazotization titration?

PRINCIPLE. The principle involved in this method is that the primary aromatic amine present in the sample reacts with the sodium nitrite in the presence of acid such as hydrochloric acid to obtain a diazonium salt.

What indicator is used in diazotization titration?

The end point in diazotization titration is detected by the following procedures: The excess of nitrous acid is determined by the addition of the starch iodide as an external indicator. After diazotization, one drop of the resulting solution is placed on the starch iodide paper which changes into dark colour.

What is Diazotisation write diazotization reaction of aniline?

Solution 2 Diazotisation: The process of conversion of a primary aromatic amino compound into a diazonium salt, is known as diazotisation. This process is carried out by adding an aqueous solution of sodium nitrite to a solution of primary aromatic amine (e.g., aniline) in excess of HCl at a temperature below 5°C.

Why titration is suitable for sodium nitrate?

Titration must be used to obtain a solution of a salt and water only, when using an acid and an alkali. This is because there is no insoluble excess reactant that could be removed by filtration .

What are the applications of diazotization titration?

Application of diazotization titration: An important pharmaceutical application of sodium nitrite titration is the analysis of sulphonamides by diazotization of primary aromatic amino group usually present in this class of drugs. Several sulphonamides require the formation of primary amine prior to diazotization step.

Which of the compound undergoes diazotization reaction?

7.9. Diazotization is an important reaction of 1° amines. In the diazotization process, the NH2 group is changed to a diazonium salt, R–N2+X−. This is done by reaction with nitrous acid (HNO2).

What is diazotization Slideshare?

 Theory: Diazotization is used in analysis of aromatic compound containing amino group in a molecule. Nitrous acid is formed by the interaction of sodium nitrite and hydrochloric acid. NaNO2 + HCl NaCl + HNO2. 5.