What is a needle free injection device?
INTRODUCTION. Needle free injection technology (NFIT) encompasses a wide range of drug delivery systems that drive drugs through the skin using any of the forces as Lorentz, shock waves, pressure by gas or electrophoresis which propels the drug through the skin, virtually nullifying the use of hypodermic needle.
How is SAIZEN administered?
SAIZEN can be administered using (1) a standard sterile disposable syringe and needle, (2) a compatible SAIZEN needle-free injection device or (3) a compatible SAIZEN needle injection device. For proper use, refer to the Instructions for Use provided with the administration device.
How is SAIZEN produced?
SAIZEN is authentic human growth hormone which is prepared from genetically engineered mammalian cells (recombinant mouse cells – C127) transformed with a bovine papilloma virus vector containing the human growth hormone coding sequence.
Does needle-free injection hurt?
The Injex system consists of two main components: the pen-sized injector and the sterile disposable ampoules. Driven by the power of a spring in the injector, the medication is pushed through the epidermis into the subcutaneous tissue. The treatment is pain-free and does not damage the skin as the needle does.
Does PharmaJet hurt?
What does the injection feel like? Not unlike traditional injections, individuals will respond differently to the needle-free injection. Some feel nothing, while others have reported feeling the pressure of the injection or a snap like a rubber band when the injection is administered.
How do you store Saizen?
Saizen® click. easy® cartridges reconstituted with the diluent containing 0.3% (w/v) metacresol in Sterile Water for Injection should be stored under refrigeration (2°-8°C/36°-46°F) for up to 21 days. Avoid freezing reconstituted vials or cartridges of Saizen®.
Who manufactures Saizen?
Merck Serono
Manufactured by Merck Serono, Saizen is produced by recombinant DNA technology from a mammalian cell line (mouse C127) that was modified by the addition of the human GH gene, resulting in an identical 191-amino acid sequence and structure.
How does painless injection work?
Painless or acellular vaccines contain fewer antigens or only some of the cellular material rather than complete cells which are found in the painful variants. Painless versions are more commonly used in the immunisation of young children and in India are still usually administered via syringe.
Is there an alternative to injections?
PharmaJet is a needle-free system that applies a high-pressure inoculation through the skin. It’s being offered as an alternative to traditional flu shots for people who have a fear of needles in many places across the country.
How long does Saizen last in the fridge?
Store in the original packaging to protect from light. After the first injection, the Saizen cartridge or the easypod™ auto-injector containing the Saizen cartridge has to be stored in a refrigerator (2°C-8°C) for a maximum of 28 days of which up to 7 consecutive days can be outside of a refrigerator at or below 25°C.
How to administration of Saizen 8 mg solution?
For administration of the reconstituted solution for injection of Saizen 8 mg click.easy follow the instructions given in the package leaflet and in the instruction manual provided with the selected auto-injector: one.click auto-injector, cool.click needle-free auto-injectors or easypod auto-injector.
What should I use to draw Saizen from a syringe?
To prevent possible contamination, wipe the rubber vial stopper with an antiseptic solution before puncturing it with the needle. It is recommended that Saizen be administered using sterile, disposable syringes and needles. The syringes should be of small enough volume that the prescribed dose can be drawn from the vial with reasonable accuracy.
Which is jet injection device for needle free administration?
Jet injection devices for the needle-free administration of compounds, vaccines, and other agents
How is Saizen used in the treatment of growth failure?
Saizen (somatropin) is indicated for the treatment of pediatric patients with growth failure due to inadequate secretion of endogenous growth hormone. Saizen is indicated for replacement of endogenous growth hormone in adults with growth hormone deficiency who meet either of the following two criteria: