What is the function of neurites?

Neurite outgrowth Neurites are small processes on developing neurons that ultimately grow out into axons or dendrites under the control of growth stimulating or inhibiting factors from their direct extracellular environment sensed by receptors in the growth cone, the tip of the neurite.

What is a neuronal cell line?

Cell lines provide a virtually unlimited supply of a homogeneous population of neurons that can be induced to differentiate at a specified time. Primary cultured neurons elaborate axons and dendrites characteristics that can be observed in vivo.

What is axon and dendrites?

Axon – The long, thin structure in which action potentials are generated; the transmitting part of the neuron. Dendrite – The receiving part of the neuron. Dendrites receive synaptic inputs from axons, with the sum total of dendritic inputs determining whether the neuron will fire an action potential.

What is neurite outgrowth?

Neurite outgrowth is a commonly used assay to study neuronal development and neuronal degeneration in vitro. Development of neurites requires a complex interplay of both extracellular and intracellular signals. The growth of neurites can be stimulated or inhibited by neurotrophic factors.

What causes neurite outgrowth?

In general, neurite outgrowth is stimulated by Rac and Cdc42 activation, while Rho activation appears to promote neurite retraction [1]. The mechanisms by which Gi/o may signal to the actin cytoskeleton are discussed below and summarized in Figure 203.5.

What are BV 2 cells?

BV-2 is a type of microglial cell derived from C57/BL6 murine. The BV2 cells are immortalized by v-raf/v-myc carrying J2 retrovirus. BV2 express nuclear v-myc and the cytoplasmic v-raf oncogene products as well as the env gp70 antigen at the surface level.

What is neuroblastoma cell line?

Neuroblastoma (NB) cell lines are transformed, neural crest derived cells, capable of unlimited proliferation in vitro. These cell lines retain the ability of differentiation into neuronal cell types on treatment with various agents.

What are neurons Class 9?

NERVOUS TISSUE A neuron consists of a cell body which comprises of nucleus and cytoplasm, from which long thin hair-like parts arise. The neuron has a single long part, called the axon, which transmit the nerve impulse to body parts. The neuron has short, branched parts called dendrites.