What is Motofen used for?

What is Motofen used for?

This medication is used to treat diarrhea. It helps to decrease the number and frequency of bowel movements. It works by slowing the movement of the intestines. Difenoxin is similar to opioid pain relievers, but it acts mainly to slow the gut.

What type of drug is Motofen?

Motofen (difenoxin hydrochloride and atropine sulfate) is an anticholinergic used to treat diarrhea.

What are some of the contraindications for atropine?

Contraindications: Atropine generally is contraindicated in patients with glaucoma, pyloric stenosis or prostatic hypertrophy, except in doses ordinarily used for preanesthetic medication.

Is Motofen a narcotic?

Motofen comes in a 5-sided, dye-free tablet that contains difenoxin (1 mg) and atropine sulfate (0.025 mg). Motofen is taken by mouth and is chemically related to the narcotic meperidine. Atropine sulfate is present to discourage deliberate overdose.

What is Motofen?

Each five-sided dye free MOTOFEN® tablet contains: 1 mg of difenoxin (equivalent to 1.09 mg of difenoxin hydrochloride) and 0.025 mg of atropine sulfate (equivalent to 0.01 mg of atropine). Atropine sulfate is present to discourage deliberate overdose.

What clinical conditions are contraindicated for the use of Difenoxin with atropine?

Pediatric use Diphenoxylate hydrochloride and atropine sulfate is contraindicated in pediatric patients less than 6 years of age due to the risks of severe respiratory depression and coma, possibly resulting in permanent brain damage or death (see CONTRAINDICATIONS).

What are the indications of atropine?


  • Antisialagogue. While atropine can be used independently for anti-salivation effects, it most commonly is secondary to anticholinergic or antimuscarinic poisoning, as discussed below.
  • Anticholinergic Poisoning.
  • Bradycardia.
  • Rapid Sequence Intubation (RSI) Pretreatment.

When should atropine not be given?

Atropine should be avoided with bradycardia caused by hypothermia and, in most cases, it will not be effective for Mobitz type II/Second-degree block type 2 or complete heart block.

Which medication is contraindicated in patients who are on Difenoxin with atropine Motofen therapy?

A subtherapeutic dose of atropine has been added to difenoxin hydrochloride to discourage deliberate overdosage. Usage of MOTOFEN® in recommended doses is not likely to cause prominent anticholinergic side effects, but MOTOFEN® should be avoided in patients in whom anticholinergic drugs are contraindicated.

Who makes Motofen?

There is currently only one manufacturer of Motofen tablets: Valeant Pharmaceuticals. It acquired the drug from Amarin Pharmaceuticals in 2004. Valeant’s tablets are pentagonal shaped, impressed with a “V” on one side, and vertically scored on the other side.

What clinical conditions are contraindicated for the use of Lomotil?

Lomotil is contraindicated in patients with diarrhea associated with organisms that penetrate the GI mucosa (toxigenic E. coli, Salmonella, Shigella), and pseudomembranous enterocolitis (Clostridium difficile) associated with broad-spectrum antibiotics (see CONTRAINDICATIONS).

What are the contraindications for motmotofen®?

Motofen ® is contraindicated in patients with diarrhea associated with organisms that penetrate the intestinal mucosa (toxigenic E. coli, Salmonella species, Shigella) and pseudomembranous colitis associated with broad spectrum antibiotics.

What are the side effects of Motofen ®?

Use with caution in patients with ulcerative colitis or liver or kidney disease. Motofen ® may produce drowsiness or dizziness. Use caution when engaging in activities requiring mental alertness, such as driving or operating dangerous machinery. Safety and effectiveness in children below the age of 12 have not been established.

What are the side effects of Motofen (difenoxin and atropine)?

If you have a lot of fluid loss, you may have more side effects from Motofen (difenoxin and atropine). Keep away from children. Accidental exposure and overdose may result in very bad breathing problems or coma. These could lead to long lasting brain damage and sometimes death.

What is motmotofen ® (difenoxin)?

Motofen ® (difenoxin and atropine sulfate tablets) is indicated as adjunctive therapy in the management of acute nonspecific diarrhea and acute exacerbations of chronic functional diarrhea.